3D convolutional neural networks for outcome prediction in glioblastoma using methionine PET and T1w MRI

Iram Shahzadi, Annekatrin Seidlitz, Alex Zwanenburg, Bettina Beuthien-Baumann, Ivan Platzek, Jörg Kotzerke, Michael Baumann, Mechthild Krause, Steffen Löck

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For treatment personalization of patients with glioblastoma, we investigate three different 3D convolutional neural networks (3D-CNN) for predicting time to recurrence (TTR) and overall survival (OS) from postoperative [11C] methionine PET (MET-PET) and gadolinium-enhanced T1-weighted magnetic resonance imaging (T1c-w MRI). The 3D-DenseNet model on MET-PET integrated with age and MGMT status achieved the best performance on independent test data (Concordance-Index: TTR=0.68, OS=0.65) with significant patient stratification (p-value: TTR=0.017, OS=0.039). After prospective validation, these models may be considered for treatment personalization.
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Friday 8th July
Poster Session 3.2 - onsite 11:00 - 12:00, virtual 15:20 - 16:20 (UTC+2)
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