Segmentation-Consistent Probabilistic Lesion Counting

Julien Schroeter, Chelsea Myers-Colet, Douglas Arnold, Tal Arbel

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Lesion counts are important indicators of disease severity, patient prognosis, and treatment efficacy, yet counting as a task in medical imaging is often overlooked in favor of segmentation. This work introduces a novel continuously differentiable function that maps lesion segmentation predictions to lesion count probability distributions in a consistent manner. The proposed end-to-end approach—which consists of voxel clustering, lesion-level voxel probability aggregation, and Poisson-binomial counting—is non-parametric and thus offers a robust and consistent way to augment lesion segmentation models with post hoc counting capabilities. Experiments on Gadolinium-enhancing lesion counting demonstrate that our method outputs accurate and well-calibrated count distributions that capture meaningful uncertainty information. They also reveal that our model is suitable for multi-task learning of lesion segmentation, is efficient in low data regimes, and is robust to adversarial attacks.
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Wednesday 6th July
Poster Session 1.2 - onsite 11:00 - 12:00, virtual 15:20 - 16:20 (UTC+2)
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